Synthetic Route of 106429-57-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106429-57-6, name is Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
methyl 2-oxo-2,3-dihydro-1H-1,3-benzimidazole-5-carboxylate (1.3 g, 6.6 mmol), pyridine hydrobromide (1.0 g, 6.6 mmol) and phosphorous oxybromide (3.7 g, 13 mmol) were mixed in EtOAc (100 ml). The reaction mixture was stirred at reflux for 7 d. Water was added. The organic phase was washed with NaHC03 (sat., aq), dried over MgS04, filtered and concentrated. The intermediate methyl 2-bromo-1H-benzimidazole-6-carboxylate was obtained in 100% yield (1.6 g). MS (ESI+) m/z 255 [M+H]+. HPLC purity: 95%. 1H NMR (600 MHz, MeOD- ) delta ppm 8.21 (s, 1 H) 7.96 (dd, J=8.55, 1.53 Hz, 1 H) 7.58 (d, J=8.55 Hz, 1 H) 3.93 (s, 3 H)
The synthetic route of Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.