Month: April 2021

Synthetic Route of 152628-02-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, SMILES is C(CC)C1=NC2=C([NH]1)C(=CC(=C2)C3=NC4=C([N]3C)C=CC=C4)C, belongs to imidazoles-derivatives compound. In a article, author is Tian, Yuan, introduce new discover of the category.

Acid-catalyzed synthesis of imidazole derivatives via N-phenylbenzimidamides and sulfoxonium ylides cyclization

A straightforward method to synthesize imidazole derivatives from amidines and sulfoxonium ylides catalyzed by acids is reported in this study. Specifically, catalyzed by trifluoroacetic acid in DCE solvents can improve synthesis efficiency under metal-free conditions. A series of imidazole scaffolds were produced in good to excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.

Synthetic Route of 152628-02-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 152628-02-9.

In an article, author is MAURICE, M, once mentioned the application of 23996-25-0, Application In Synthesis of 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, Name is 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, molecular formula is C9H13N3, molecular weight is 163.22, MDL number is MFCD00051492, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

EFFECTS OF IMIDAZOLE DERIVATIVES ON CYTOCHROMES-P450 FROM HUMAN HEPATOCYTES IN PRIMARY CULTURE

The expression of several forms of cytochrome P450 including P450 1A2, 2D6, 2E1 and 3A was investigated in human hepatocytes maintained in primary culture for 96 h in the absence or presence of 50-mu-M of various imidazole derivatives. These included ketoconazole, clotrimazole, miconazole, fluconazole, secnidazole and metronidazole. In addition, the typical inducers rifampicin and beta-naphthoflavone were used for comparison. Western and Northern blot analysis of microsomes and RNA prepared from these cultures as well as de novo synthesis experiments revealed that, among the imidazole derivatives tested, only clotrimazole was a strong rifampicin-like inducer of P450 3A. The expression of the other forms of P450 tested was not affected by the treatments. Analysis of the inhibition of 13 monoxygenase activities, including ethoxyresorufin and phenacetin O-deethylases, coumarin 7-alpha-, lauric acid 11- and 12-, mephenytoin 4-, debrisoquin 4-, and aniline hydroxylases, benzphetamine, aminopyrine, mephenytoin and erythromycin demethylases, and cyclosporin oxidase (representative of 10 different forms of P450 in human liver microsomes) revealed that ketoconazole was a strong and selective in vitro inhibitor of P450 3A (cyclosporin oxidase) with a K(i) < 1-mu-M. Clotrimazole and miconazole were also strong inhibitors of P450 3A-mediated activities in contrast to the other imidazole derivatives. If you are interested in 23996-25-0, you can contact me at any time and look forward to more communication. Application In Synthesis of 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile.

Related Products of 641571-11-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, SMILES is CC1=C[N](C=N1)C2=CC(=CC(=C2)N)C(F)(F)F, belongs to imidazoles-derivatives compound. In a article, author is Majumdar, K. C., introduce new discover of the category.

Indium(III) Chloride Catalyzed One-Pot Multicomponent Synthesis of Chromenone- and Quinolone-Annulated Imidazole Derivatives

A one-pot multicomponent strategy for the synthesis of chromenone- and quinolone-annulated imidazole derivatives from easily available starting materials has been achieved via an indium(III) chloride catalyzed domino reaction. The protocol is simple, step-economic, and less hazardous, and also provides good yields of the products.

Related Products of 641571-11-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 641571-11-1 is helpful to your research.

Electric Literature of 25676-75-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 25676-75-9, Name is 4-Bromo-1-methylimidazole, SMILES is CN1C=NC(Br)=C1, belongs to imidazoles-derivatives compound. In a article, author is Reddy, KR, introduce new discover of the category.

Palladium-imidazole derivatives as highly active catalysts for Heck reactions

N-Substituted 2-(2-bromophenyl)benzimidazole derivatives have been synthesized and used in palladium catalyzed Heck reactions to give coupled products in good yields. (C) 2004 Elsevier Ltd. All rights reserved.

Electric Literature of 25676-75-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 25676-75-9 is helpful to your research.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 3543-73-5, Name is Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, formurla is C14H19N3O2. In a document, author is Mohan, S., introducing its new discovery. Product Details of 3543-73-5.

Nano-Silica Catalyzed Synthesis, Solvent Effect, NMR Spectral and DFT Studies of Some Imidazole Derivatives

A series of novel imidazole derivatives has been designed and synthesized using nano-SiO2 as an efficient catalyst. Synthesized compounds have been characterized by H-1 and C-13-NMR spectral studies. The significant features of this nanocatalyst are high product yield, short reaction times and a vast range of substrates usage. Proton and C-13 chemical shifts of the synthesized compounds were calculated. The absorption and emission properties of imidazole derivatives were studied in several solvents. Polar solvents favor the stabilization of excitation of the imidazole derivative. Decrease in the total dipole moment of the solvent molecules (non-polar solvents) results in the change of the molecular charge distributions of the imidazole derivatives. Optimization of 4,5-dimethyl-2-phenyl-1-m-tolyl-1H-imidazole (1) was performed by DFT at B3LYP/6-31G (d, p) using Gaussian-03.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 3543-73-5 help many people in the next few years. Product Details of 3543-73-5.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, molecular formula is C7H7N3. In an article, author is Wang Shu-Jun,once mentioned of 934-32-7, Computed Properties of C7H7N3.

Chiral Zn prophyrin: Thermodynamic properties and theoretical calculation

The thermodynamic properties of chiral zinc prophyrin (ZnP) coordinating with imidazole derivatives were studied by means of UV-Vis and circular dichroism spectra. The binding constants decreased in the order of K(2-MeIm)>K(Im)>K(N-MeIm)>K(2-Et-4-MeIm) for imidazole derivatives. The results show that the capability of axial coordination increases in the sequence of 2-Et-4-MeImComputed Properties of C7H7N3.

In an article, author is Jayabharathi, Jayaraman, once mentioned the application of 60-56-0, Category: imidazoles-derivatives, Name is 1-Methyl-1H-imidazole-2(3H)-thione, molecular formula is C4H6N2S, molecular weight is 114.1688, MDL number is MFCD00179321, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

Fluorescence spectral studies of some imidazole derivatives

The photophysical properties of imidazole derivatives namely 2-(2,4-difluorophenyl)-4,5-dimethyl-1-p-tolyl-1H-imidazole and N,N-dimethyl-4-(4,5-dimethyl-2-phenyl-1H-imidazol-1-yl)benzenamine,synthesized from an unusual four components assembling, were studied in several solvents. Polarization also plays major role in the increase of excited-state dipole moment (mu(e)). From the spectral results, it was found that there is equilibrium between neutral species and monocationic (MC) species in polar aprotic and polar protic solvents. The basicity of the solvent, C-beta or C-SB has a negative value, suggesting that the absorption and fluorescence bands shift to lower energies with increasing electron-donating ability of the solvent. Therefore, resonance structures 1b and 2b has the positive charge located at the nitrogen atom stabilized in basic solvents. (C) 2012 Elsevier B.V. All rights reserved.

If you are interested in 60-56-0, you can contact me at any time and look forward to more communication. Category: imidazoles-derivatives.

Let¡¯s face it, organic chemistry can seem difficult to learn, Formula: C4H5BrN2, Especially from a beginner¡¯s point of view. Like 25676-75-9, Name is 4-Bromo-1-methylimidazole, molecular formula is imidazoles-derivatives, belongs to imidazoles-derivatives compound. In a document, author is Guijarro, Albert, introducing its new discovery.

Isoprene-mediated lithiation of imidazole derivatives: mechanistic considerations

The isoprene-mediated lithiation, with lithium metal, of different imidazole derivatives is an interesting methodology for their functionalization. Studies of different possible intermediates involved in the reaction employing density functional theory calculations, at the B3LYP/6-311++G(d,p) level are considered. A plausible mechanism is described, in which isoprene is reduced, to the corresponding radical anion, in the presence of Li-(s), acting then as a base deprotonating N-methylimidazole (NMI) and producing the 1,1-dimethylallyl radical. This radical is further reduced by the excess of lithium proceeding once more as a base. This final step produces stable final products that compensate the previous equilibriums, making favourable the whole process.

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 820959-17-9, Name is Ac-Beta-Ala-His-Ser-His-OH, formurla is C20H28N8O7. In a document, author is Navas, JM, introducing its new discovery. Name: Ac-Beta-Ala-His-Ser-His-OH.

Induction of CYPIA by the N-imidazole derivative, 1-benzylimidazole

Xenobiotics can induce cytochrome P4501A (CYP1A) by ligand binding to the aryl hydrocarbon receptor (AhR). Typical AhR ligands are polycyclic aromatic compounds with planar molecular conformation. The present work investigated the ability of the N-imidazole derivative, 1-benzylimidazole (BIM), to induce CYP1A in rainbow trout hepatocytes. Benzylimidazole increased hepatocellular CYP1A catalytic activity (determined as 7-ethoxyresorufin-O-deethylase [EROD] activity) and CYP1A mRNA in a concentration-dependent way. Computational studies on the molecular structure of BIM indicated that the energetically most stable BIM conformer has the imidazole ring and the phenyl ring in different planes, i.e., does not take a planar conformation. This property of BIM does not agree with the structural requirements of a typical AhR ligand. In line with this observation, we found that the AhR antagonist, alpha-naphthoflavone (alphaNF), was not able to inhibit BIM induction of EROD activity and CYP1A mRNA, although it inhibited the induction of CYP1A by the prototypic AhR ligand, alpha-naphthoflavone (betaNF). The results suggest that transcriptional activation of CYP1A by the N-imidazole derivative, BIM, is not mediated through direct ligand binding to the AhR.

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Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 1072-62-4, Name is 2-Ethyl-1H-imidazole. In a document, author is Tanitame, A, introducing its new discovery. Category: imidazoles-derivatives.

Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring

The 4-piperidyl moiety and the pyrazole ring in 1-(3-chlorophenyl)-5-(4-phenoxyphenyl)-3-(4-piperidyl)pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, were transformed to other groups and the in vitro antibacterial activity of the synthesized compounds was evaluated. The selected pyrazole, oxazole and imidazole derivatives showed moderate inhibition against DNA gyrase and topoisomerase IV with similar IC50 values (IC50 = 9.4-25 mug/mL). In addition, many of the pyrazole, oxazole and imidazole derivatives synthesized in this study exhibited potent antibacterial activity against quinolone-resistant clinical isolates and coumarin-resistant laboratory isolates of Gram-positive bacteria with minimal inhibitory concentration values equivalent to those against susceptible strains. (C) 2004 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1072-62-4 help many people in the next few years. Category: imidazoles-derivatives.