Adding a certain compound to certain chemical reactions, such as: 288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-32-4, Recommanded Product: 288-32-4
Example L Procedure for the synthesis of [L-DIMETHYLSULFAMOYL-2-T-BUTYLDIMETHYLSILYL IMIDAZOLE] (Formula 13) N CISO2NMe2 N 1) n-BuLi.-78C N/ C Si – N”N’N H Et3N, benzene % 2) TBDMSCI S02NMe2 S02NMe2 Intermediate L1 Intermediate L2 Formula 13 Imidazole (Intermediate [LL,] available from Aldrich, 20.0 g, 0.29 mol), triethylamine [(41.] 0 mL, 0.29 mol) [AND N, N DIMETHYLSULFAMOYL] chloride (31.6 [ML,] 0.29 mol) were added to benzene (320 mL). The reaction was stirred for 48h at rt and then filtered. The filtrate was collected and concentrated under reduced pressure. Vacuum distillation of the crude produc (-0. 5 [MMHG,] [115-118 C)] afforded dimethylsulfamoyl) imidazole (Intermediate L2) 38.7 g (76%) as a clear and colorless oil. Upon cooling the product solidifies to give white crystals. 1- (Dimethylsulfamoyl) imidazole (Intermediate L2) (18.8 g, 0.11 mol) was added to THF (430 mL). The solution was cooled [TO-78 C.] A solution of n-BuLi (70.9 [ML,] 1.6 M in hexane) was added dropwise to the reaction mixture. Upon completion, the solution was stirred for lh [AT-78 C. T-BUTYLDIMETHYLSILYLCHLORIDE (TBSC1)] (17.8 g, [0. 12] mol) in THF (50 [ML)] was added via cannula to the mixture. After the addition was completed the reaction mixture was warmed slowly to rt and stirred for 24h. The mixture was diluted with water and the organic layer separated. The organic phase was washed with brine and then dried over [NA2S04.] The mixture was filtered and the filtrate concentrated under reduced pressure. Column chromatography on [SI02] with 20% ethyl acetate/hexane afforded [1-DIMETHYLSULFAMOYL-2-T-BUTYLDIMETHYLSILYL] imidazole (Formula 13) as a light yellow solid. Recrystallization from pentane gave 30 g (94%) of white crystals.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole, other downstream synthetic routes, hurry up and to see.