These common heterocyclic compound, 930-62-1, name is 2,4-Dimethylimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H8N2
Preparation of 2-(2,4-dimethyl-1H-1-yl)benzonitrile Sodium hydride (8.65 g 60%, 0.216 mol) were stirred in anhydrous dimethylformamide in 75 . Thus in the 100 2,4- dimethyl DMF was added dropwise to a solution of imidazole (20.75 g, 0.216 mol). After stirring for 1 hour at room temperature, it was added dropwise a solution of benzonitrile (23.0 , 0.216 mol) of 2-fluoro-75 of DMF. This was stirred for 2 hours at 50 , was stirred at room temperature for 16 hours. The mixture was poured into water and the product was extracted with ethyl acetate. The organic layer was washed with water, dried over sodium sulfate. The crude product was 19: 1 dichloromethane-methanol followed by 9: 1 dichloromethane-treated by chromatography (silica gel) eluting with methanol to give the product as a solid. LCMS data were confirmed the structure.
The synthetic route of 2,4-Dimethylimidazole has been constantly updated, and we look forward to future research findings.