Related Products of 95470-42-1, These common heterocyclic compound, 95470-42-1, name is Ethyl 2-bromo-4-methyl-1H-imidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) Ethyl 2-bromo-4-methyl-i H-imidazole-5-carboxylate (1.52 g, 6.0 mmol), (4-chlorobenzo[b]thiophen-3-yl)metha- nol (1.79 g, 9.0 mmol) obtained according to a method described in a literature (for example, WO 2002/066457), and triphenylphosphine (2.36 g, 9.0 mmol) were dissolved in THF (15 mE), a 1.9 M solution of DIAD in toluene (4.73 mE, 9.0 mmol) was added dropwise thereto under cooling at 0°C., and the mixture was stirred at 30°C. for 10 hours. The solvent was distilled away and the residue was purified by colunm chromatography to obtain ethyl 2-bromo-i ((4-chlorobenzo [b]thiophen-3-yl)methyl)-4-methyl- 1 H-imidazole-5-car- boxylate (1.73 g):10138] ?H-NMR (CDC13) oe: 7.72 (1H, d, J=8.3 Hz), 7.41-7.24 (3H, m), 6.15 (2H, s), 4.21 (2H, q, J=7.1 Hz), 2.57 (3H, s), 1.20 (3H, t, J=7.1 Hz);10139] ESI-MS mlz=413 (M+H).
The synthetic route of 95470-42-1 has been constantly updated, and we look forward to future research findings.