Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Formula: C7H5ClN2
To a solution of 2-chloro-1H-benzimidazole (3.8 g) in DMF (25 ml) was added sodium hydride (60% in oil, 1.1 g) at 0 C. in several portions. The reaction mixture was stirred at 0 C. for 30 min, 2-(trimethylsilyl)ethoxymethyl chloride (4.7 ml) was added dropwise, and the mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by basic silica gel column chromatography (hexane/ethyl acetate) to give the title compound (6.3 g). [0427] 1H NMR (300 MHz, CDCl3) 5-0.05 (9H, s), 0.87-0.95 (2H, m), 3.55-3.61 (2H, m), 5.57 (2H, s), 7.27-7.36 (2H, m), 7.42-7.50 (1H, m), 7.66-7.74 (1H, m).
The synthetic route of 4857-06-1 has been constantly updated, and we look forward to future research findings.