Extended knowledge of 1-Methyl-1H-imidazole-2-carboxylic acid

The synthetic route of 20485-43-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H6N2O2

Given that A’l4-mcthyl substituted tubulysins (such as A14-desacetoxytubulysin H, (Nicolaou, et al., 2016; Wipf & Wang, 2007) Tbl) have been proven more potent than their L’|4-H and A14-acetoxytubulysin (such as tubulysin H) coimterparts, considerable efforts were focused on designing and synthesizing a number of A’l4-mcthyl substituted tubulysins. Scheme 4 summarizes the synthesis of A’l4-mcthyl substituted tubulysins Tb50 and Tb51, in which the pipecolic acid residue of the molecule is replaced with pyrrole and A-Me substituted imidazole structural motifs, respectively. Thus, cleavage of the Fmoc protecting group from previously synthesized intermediate 22 through the action of | A’, A’-b i s(2-am i nocthy 1 )- 1.2- ethanediamine] followed by coupling of the so generated amine with 1 -methyl- lA-pyrrole-2 -carboxylic acid (23) and 1 -methyl- lA-imidazole-2-carboxy lie acid (24) provided Al4-dcsacctoxy tubulysin analogues Tb50 and Tb51, in 74% and 76% yields, respectively, as summarized in Scheme 4.

The synthetic route of 20485-43-2 has been constantly updated, and we look forward to future research findings.