Some common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1072-84-0
For synthesis of methyl imidazole-4-carboxylate (5), conc. H2SO4(1.5 mL) was added to a suspension of Im-CO2H (1.00 g, 8.92 mmol)in MeOH (20 mL), and themixture was refluxed for 24 h to give a solutionthat was then cooled to 0 C and neutralized to pH 8 using 5 MNaOH. Evaporation in vacuo left a white residue that was re-dissolvedin a minimal volume of boiling water; cooling the solution depositedwhite crystals of the ester that were collected, washed with cold H2O(1 × 5 mL), and dried in vacuo at r.t. for 24 h. Yield: 0.87 g (77%). 1HNMR (DMSO-d6): delta 7.74 (s, 1H, H5-Im), 7.65 (s, 1H, H2-Im), 2.51 (s,3H, CH3-Im). IR: 3105 (N-H, s), 2976, 2846 (C-H, m), 1619 (C=O,m), 1363 (s), 1156 (m), 864 (m). ESI-MS: 127 (M+). Anal. Calcd. forC5H6N2O2: C, 47.62; H, 4.80; N, 22.21. Found: C, 47.5; H, 4.85; N, 21.7.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1072-84-0, its application will become more common.