Reference of 33016-47-6, The chemical industry reduces the impact on the environment during synthesis 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.
1-Trityl-1H-imidazole-4-carboxaldehyde (Daminos-Zeghal S. et al., Tetrahedron, 1997, 53(22), 7605-14) (5 g; 14.8 mmol) is dissolved in dichloromethane (35 ml) under a nitrogen atmosphere and then cooled to -78 C. Methyl trifluoromethanesulfonate (1.7 ml; 14.8 mmol) is added dropwise and the reaction mixture is allowed to warm slowly to room temperature (over 2 hours). Phosphate buffer solution (pH 7; 50 ml) is added and the two-phase mixture is stirred vigorously for 15 minutes. The two phases are then separated and the aqueous phase is extracted three times with dichloromethane. The organic phases are combined, dried over magnesium sulfate, filtered and concentrated. The orange-colored solid obtained is purified by flash chromatography (CH2Cl2, then 10/90 acetone/CH2Cl2 and then 5/95 MeOH/CH2Cl2) to give the desired product (1.39 g; 85%). [0250] 1H NMR, DMSO-d6 (ppm): 3.87 (s, 3H); 7.88 (s, 1H); 8.00 (s, 1H); 9.75 (s, 1H).
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