Electric Literature of 30148-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
(S)-[2-(hydroxydim-tolylmethyl)pyrrolidin-1-yl](1-methyl-imidazol-2-yl)methanone was first prepared by dissolving (S)-a,a-Di(3-methylphenyl)prolinol (prepared as described above, 0.8 g, 2.85 mmol) in toluene (10 mL) and NaH (60 % dispersion in mineral oil, 148 mg,3.7 mmol) added at room temperature. After stirring for 30 mins, ethyl-1-methylimidazole-2-carboxylate (527 mg, 3.4 mmol) was added. The resulting reaction mixture was slowly warm to 70 C and stirred for 24 h at the same temperature. The reaction was cooled to room temperature, quenched by addition of saturated aqueous NH4CI (20 mL) and extracted with dichloromethane (3 x 20 mL). The combined organic extracts were washed with brine (20 mL) and dried over magnesium sulfate. After filtration, the filtrate was evaporated and purified by chromatography on silica gel (10% to 50% ethyl acetate in petroleum ether) to yield the product (0.53 g, 48 %) as white solid; m.p. 162-164C;[a]D-95.5 (c1 .1 in CHCI3);vmax (thin film, cm -1) 2952, 1615, 1456, 1282; deltaEta (500 MHz, d6-DMSO, 100 C) 1 .66-1 .75 (m, 1 H, 1 xCH2), 1 .78-1 .86 (m, 1 H, 1 chi CH2), 1 .93-1 .97 (m, 1 H, 1 chi CH2), 2.05-2.12 (m, 1 H, 1 chi CH2), 2.14 (s, 3H, CH3), 2.29(s, 3H, CH3), 3.36 (s, 3H, NCH3), 3.47-3.52 (m, 1 H, 1 chi CH2), 3.87- 3.92 (m, 1 H, 1 x CH2), 5.68 (s, 1 H, NCH), 6.14 (br, s, 1 H, OH), 6.85-6.87 (m, 2H, ArH), 6.91 – 6.98 (m, 4H, ArH), 7.04 (app. d, 1 H, J 7.7, ArH), 7.18-7.24 (m, 2H, ArH), 7.28 (s, 1 H, ArH); deltaC (126 MHz, d6-DMSO, 100C) 20.6(2 x CH3), 22.2(CH2),27.2 (CH2), 33.6 (CH3),47.4(NCH2), 63.5(NCH), 80.1 (COH), 123.2, 123.3, 123.6, 125.3, 125.9, 126.2, 126.6, 126.9, 127.2, 135.2, 136.1 , 140.2, 145.3, 145.4, 158.9 ( CO) ;mlz (TOF ES+) 390.2188 (100%, MH+, C24H28N3O2 requires 390.2182), 372.2092 (20).
The synthetic route of Ethyl 1-methyl-1H-imidazole-2-carboxylate has been constantly updated, and we look forward to future research findings.