The synthetic route of 2-Chloro-6-(trifluoromethyl)benzimidazole has been constantly updated, and we look forward to future research findings.
Electric Literature of 86604-86-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 86604-86-6, name is 2-Chloro-6-(trifluoromethyl)benzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 2: 3-Phenyl-8-r5-(trifluoromethyl)-1 H-benzimidazol-2-yll-1-oxa-3,8-diazaspiro- [4.51decan-2-one; 2-Chloro-5-(trifluoromethyl)-1 H-benzimidazole (Intermediate 1 , 50 mg, 0.227 mmol), which is commercially available or can be prepared according to the procedure described herein, was dissolved in DMSO (1.5 ml). 3-Phenyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrobromide (for a preparation see US4244961 , 78.1 mg, 0.249 mmol) and DIPEA (0.1 19 ml) were added. The mixture was irradiated in a microwave twice at 150 0C for 30 min. The mixture was passed through a SPE-SCX cartridge eluting with DCM, MeOH and 2M ammonia in methanol in this order. The basic fractions were evaporated and the residue was purified by silica gel chromatography eluting with cyclohexane/EtOAc/MeOH: 1/1/0 to 9/9/2 to give the title compound (20.0 mg, 21.2%). 1 H-NMR (500 MHz, DMSO- d6): delta 11.86 (1 H, br s), 7.57 (2H, d), 7.45 (1 H, br s), 7.40 (2H, t), 7.34 (1 H, d), 7.26 (1 H, d), 7.14 (1 H, t), 3.93 (2H, s), 3.81-3.88 (2H, m), 3.55-3.65 (2H, m), 1.91-2.06 (4H, m); HPLC-MS, 2: 2.69 min, m/z 417 [M+H]+.
The synthetic route of 2-Chloro-6-(trifluoromethyl)benzimidazole has been constantly updated, and we look forward to future research findings.