Electric Literature of 615-16-7,Some common heterocyclic compound, 615-16-7, name is 2-Hydroxybenzimidazole, molecular formula is C7H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a three flask equipped with a thermometer dichloroethane solvent 1000ml, added slowly with stirring 268gBenzimidazolone. Meanwhile weighed 305g of fuming nitric acid (concentration ?95%), and slowly poured three bottles, while down while stirring. Then added phosphorus pentoxide 20g. Reflux, the reaction temperature is 85 , TLC tracking dinitro compound detected is generated to stop the reaction. While recovering the solvent was concentrated under reduced pressure, water was added, extraction dichloroethane, and the solvent was evaporated to dryness to give the product recovered organic phase was dried over anhydrous sodium sulfate. 381g dried to give a solid, a yield of 85.1%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Hydroxybenzimidazole, its application will become more common.