Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 872-49-1, name is 5-Chloro-1-methylimidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloro-1-methylimidazole
An acetonitrile (6 ml) solution of 2,5-difluorobenzaldehyde (327 mul, 3 mmol), 5-chloro-1-methylimidazole (187 mug, 2 mmol) and di-t-butyl dicarbonate (504 mul, 2.2 mmol) was stirred at room temperature for 20 hours. The precipitate thus formed was collected by filtration, followed by trituration with hexane to give the title compound (472 mg, 66%) as a white solid. 1H-NMR (400MHz, CDCl3) delta: 1.48(9H,s), 3.67(3H,s), 6.88-7.1 (4H, m), 7.39 (1H, m). mp: 125 to 126C. MSm/z: 359 (M++H) .
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.