Synthetic Route of 2849-93-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2849-93-6 name is 1H-Benzimidazole-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0401] To a 4 mL sample vial equipped with a magnetic stir bar was placed benzyl (7-amino-5-((2S,4S)-1-((R)-2-amino-3-cyclohexylpropanoyl)-4-(5-(2-hydroxypropan- 2-yl)-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxamido)-6,7-dioxoheptyl)carbamate (Intermediate L, 20 mg, 0.028 mmol, 1.0 equiv), 1H-benzo[d]imidazole-2-carboxylic acid (10 mg, 0.062 mmol, 2.2 equiv), HATU (12.7 mg, 0.033 mmol, 1.2 equiv) and DMF (400 muL). The solution was treated with EtN(iPr)2 (15 muL, 0.083 mmol, 3 equiv) and the mixture was stirred at room temperature for 18 h overnight. The reaction mixture was filtered through a 13 mm 0.45 muM PFTE syringe filter and the filtrate was collected. Purification of the filtrate by reverse-phase column chromatograph (Waters XSelect CSH Prep C18, 5 mum, 30 × 75 mm) using 60:40 to 35:65 H2O:MeCN + 0.1% HCO2H as a gradient over 10 minutes afforded the title compound. MS (ESI+) 826 (M+1) ^
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Benzimidazole-2-carboxylic acid, and friends who are interested can also refer to it.