Application of 71759-89-2, A common heterocyclic compound, 71759-89-2, name is 5-Iodo-1H-imidazole, molecular formula is C3H3IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1:To a 000 mixture of AlOa (2.0 g, 10.3 mmol) (Synthonix) in anhydrous THF (40 mL) is added NaH (60% in oil, 495 mg, 12.4 mmol). The resulting mixture is stirred for 10 mm before the addition of (3-bromo-propoxymethyl)benzene (2.3 mL, 12.9 mmol) (Chembridge-BB). The resulting mixture is allowed to warm to RT, and then is stirred overnight. An aqueous solution of saturated NH4CI (20 mL) is added, and this mixture is stirred for 10 mm. The mixture is extracted with EtOAc (3x) and the layers are separated. The organic layer is washed with water,brine, dried with MgSO4 and concentrated to provide crude material that is purified by Combif lash (20:80 to 80:20, EtOAc/hexanes) to provide A22a.
The synthetic route of 71759-89-2 has been constantly updated, and we look forward to future research findings.