Related Products of 5805-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5805-57-2 name is (1H-Benzo[d]imidazol-2-yl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a round bottom flask a mixture of (1H-benzo[d]imidazol-2-yl)methanamine (58; 720 mg, 3.8 mmol), 4,7-dichloroquinoline (1.07 g, 5.39 mmol) and phenol (2.33 g, 24.74 mmol) was heated for 3.5 h at 130 C, stirring under N2. After cooling, the mixture was dissolved in a solution of CH2Cl2/MeOH (95:5) and surplus of phenol was extracted with 2 N NaOH. The organic layers were washed with water, brine, dried over anhydrous Na2SO4 and evaporated to dryness. The crude solid was purified by CC on silica gel (CH2Cl2/MeOH; 93:7). The resulting product was rinsed with diethyl ether.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-Benzo[d]imidazol-2-yl)methanamine, and friends who are interested can also refer to it.