Some common heterocyclic compound, 1546-79-8, name is 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, molecular formula is C5H3F3N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1546-79-8
To a solution of 5 (1.54 g, 2.67 mmol) in THF (40 mL) was added 1-(trifluoroacetyl)imidazole (365 mL, 3.20 mmol), and the whole was heated for6 h under reflux. After being cooled to room temperature, the reactionmixture was quenched by addition of ice, and the solvent was removedin vacuo. The residue was partitioned between AcOEt and H2O. The separatedorganic layer was further washed with H2O (twice) and saturatedaqueous NaHCO3, followed by brine. The separated organic layer wasdried and concentrated in vacuo. The residue was purified by a silica gelcolumn, eluted with MeOH in CHCl3 (0%-4%), to give 6 (1.30 g, 84% asa white solid): ESI-LRMS m/z 601 (MNa); ESI-HRMS calcd forC29H54N4O4NaSi2 601.3581, found 601.3539; 1H NMR (400 MHz, CDCl3)d 7.73 (1 H, s, H-2), 7.01 (1 H, br s, NH2, exchangeable with D2O), 6.09(1 H, dd, H-1?, J5.4, 8.3 Hz), 5.39 (1 H, br s, NH2, exchangeable withD2O), 4.88 (1 H, d, CH2, J18.0 Hz), 4.72 (1 H, dd, H-3?, J2.3, 5.3 Hz),4.13-4.08 (2 H, m, H-4?,CH2), 3.90-3.83 (2 H, m, H-5?), 2.55 (1 H, ddd,H-2?a, J5.4, 13.0, 2.3 Hz), 2.44 (1 H, ddd, H-2?b, J8.3, 13.0, 5.3 Hz),1.16-1.02 (42 H, m, TIPS); 13C NMR (100 MHz, CDCl3) d 165.08, 134.74,132.94, 124.22, 115.69, 89.14, 85.36, 72.78, 63.57, 42.63, 18.09, 18.06,13.14, 12.18, 11.99.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1546-79-8, its application will become more common.