Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39070-14-9, name is (1-Methyl-2-nitro-1H-imidazol-5-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: (1-Methyl-2-nitro-1H-imidazol-5-yl)methanol
Step 2: To a solution of compound G2 (3.41mmol) in THF cooled to -12C was added dropwise phosphorus oxychloride (5.12 mmol). The reaction mixture was stirred at -12C for 40minutes and then, proton sponge (13.64mmol) was added. The reaction mixture was stirred at -12C overnight. To this stirred reaction mixture was added a solution of benzylamine (3.75mmol) and triethylamine (17.05mmol) in acetonitrile (7mL).The reaction mixture was then allowed to warm to -5C. The reaction mixture was stirred for 5 hours. The reaction was monitored by LC/MS. To the reaction mixture was then added a solution of (3-methyl-2-nitro-3H-imidazol-4-yl)-methanol (10.23mmol) and 4-(dimethylamino)pyridine (10.23 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature overnight, and then concentrated under reduced pressure. The crude residue was partitioned between a 5% solution of citric acid and ethyl acetate. The organic layer was washed with water and brine, dried over over sodium sulfate, filtered and concentrated under reduced pressure. The crude residue was purified by flash chromatography on silica gel (DCM/methanol: 0 to 3%) to afford the expected compound G3.
According to the analysis of related databases, 39070-14-9, the application of this compound in the production field has become more and more popular.