Application of 4887-80-3, These common heterocyclic compound, 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 92; 4-(lH-Benzoimidazol-5-yloxy)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4- ylamino)-benzamide; Example 92A; lH-Benzoimidazol-5-ol; [0458] A solution of 5-methoxybenzimidazole (500 mg, 3.374 mmol) in 48% hydrobromic acid (10 mL) was refluxed for 2 hours. The reaction was cooled to room temperature, the solvent removed by rotary evaporation under vacuum, and the residue azeotroped with toluene (50 mL) to provide the title compound as a tan solid (701 mg, 96%).
The synthetic route of 4887-80-3 has been constantly updated, and we look forward to future research findings.