Electric Literature of 116568-17-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 116568-17-3 as follows.
Example 18; 4-Benzylpiperidine-l-carboxylic acid (lH-benzoimidazol-5-carbonyl)-amide [the other tautomeric form of the compound is 4-benzyIpiperidin-l-carboxylic acid (3H-benzoimidazol-5-carbonyl)-amide1; To a Suspension of 0.947 g (3.08 mmol) of lH-benzoimidazol-5-carboxylic acid amide [Bull. Chem. Soc. Jpn., 31j 252 (1958)] in 50 ml of 1,2-dichloroethane 0.5 ml (5.7 mmol) of oxalyl chloride is added and the mixture is stirred at 90 C for 5.5 h. The reaction mixture is cooled to room temperature and 2.65 ml (15 mmol) of 4-benzylpip.eridine is added. The so obtained mixture is stirred at room temperature overnight, then concentrated and the residue is purified by column chromatography using Kieselgel 60 aes adsorbent (Merck) and Chloroform : methanol = 9 : l aes eluent to yield 145 mg (13 %) of the title compound. Mp.: 168-175 C .
According to the analysis of related databases, 116568-17-3, the application of this compound in the production field has become more and more popular.