Electric Literature of 33468-69-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of 0.8 g of the intermediate compound 2-3, 0.36 g of 4-(trifluoromethyl)imidazole and toluene were added 0.74 g of potassium carbonate, 0.26 mL of trans-N, N?-dimethylcyclohexane-1,2-diamine and 0.15 g of copper iodide. The reaction mixtures were stirred at 120 C. for 24 hours, and cooled to room temperature, and thereto was added water, and the mixtures were extracted with ethyl acetate. The obtained organic layers were washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to a silica gel column chromatography (hexane:ethyl acetate=3:2) to obtain the compound A-12 of the present invention 0.32 g. (1689) Compound A-12 of the present invention: 1H-NMR (CDCl3) delta: 1.37 (3H, t), 3.41-3.49 (2H, m), 6.49 (1H, d), 6.66 (1H, s), 7.54 (1H, d), 7.70-7.76 (2H, m), 8.04 (1H, s), 8.50 (1H, d), 8.90 (1H, d).
The synthetic route of 4-(Trifluoromethyl)-1H-imidazole has been constantly updated, and we look forward to future research findings.