Adding a certain compound to certain chemical reactions, such as: 3034-38-6, name is 5-Nitro-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3034-38-6, Recommanded Product: 5-Nitro-1H-imidazole
Synthesis of LXX:To stirred solution of 4-nitro-1H-imidazole (LXIX, 5g: 44 mmol) in acetonitrile (20 mL) was added K2C03 (18.2 g, 137 mmol) at 0C, followed by addition of methyl iodide (8.9 mL, 57mmol). The reaction mixture was heated at 95C for 3h. The reaction mixture was concentrated, filtered through a celite bed and diluted with water. The aqueous layer was extracted with chloroform and the separated organic layer was washed with brine solution and dried over anhydrous Na2SO4 before being filtered and evaporated under reduced pressure to afford 1-methyl-4-nitro-1H-imidazole (LXX, 4g, 71%). ?H NMR (400 MHz, DMSO-d6) oe 8.35 (s, 1H), 7.8 (s, 1H), 3.74 (s, 3H). MS (M+1): 128.
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