Some common heterocyclic compound, 2302-25-2, name is 4-Bromo-1H-imidazole, molecular formula is C3H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C3H3BrN2
To a stirred solution of 4-bromo-1 /-/-imidazole (5.0 g; Aldrich Chemical Company,Inc., Milwaukee, Wl) in 100 ml_ anhydrous THF at -78C in an oven dried 500 ml_ 3 necked-round bottom flask was added t-butyl-lithium (48.0 ml_, 1.7 M in pentane) dropwise over 45 minutes with a dropping funnel. After complete addition, the mixture was warmed to about 100C to 15C for 2 hours and then it was cooled to -78C, and a cold (-780C) solution of diisopropyl disulfide (6.78 ml_) in 30 ml_ THF was added via cannula. The reaction was stirred for 16 hours allowing the bath to warm. The pale yellow solution was quenched with saturated NH4CI followed by neutralization with 10% HCI. The layers were separated and the aqueous extracted with THF three times. The combined organics were dried over MgSO4 and purified by flash chromatography (40+M, 100:0, 95:5, 90:10 ethyl acetate/methanol) to afford 3.3767 g of (l-6a); m/z 143.0 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2302-25-2, its application will become more common.