Reference of 137049-00-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To 5-phenyl-3-(4-piperidinyl)-1 H-indole-7-carboxamide (40 mg, 0.12 mmol) in methylene chloride (5mL) at O0C, 1 -methyl-1 H-imidazoie-4-sulfonyl chloride (27.1 mg, 0.14 mmol) and triethylamine (0.07 ml_, 0.50 mmol) were added. The reaction mixture was stirred at O0C for 30 min. Then the reaction mixture was partitioned between methylene chloride and water, the aqueous layer was extracted with methylene chloride (25 ml_x2) and combined organic phase was dried with Mg2SO4 and concentrated by reduce pressure, and purified by Gilson HPLC (reverse phase, eluting with CH3CN/Water, 0.1 % TFA, 10/90, v/v, over 15 min) to give the title compound (22.5 mg, 39%). LC/MS: m/z, 463.4 (M+H), 1.72 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.