Some common heterocyclic compound, 36947-68-9, name is 2-Isopropyl-1H-imidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-Isopropyl-1H-imidazole
EXAMPLE 3 2-Isopropyl-4,5-dihydroxymethylimidazole 110 g (1 mole) of 2-isopropylimidazole and 220 g (2.2 moles) of a 30% strength aqueous formaldehyde solution are stirred for 1 hour at 60 C., 50.4 g (0.44 mole) of triethylamine are added to the mixture, and stirring is continued under reflux at about 78 C. The product crystallizes out from the mixture. After 48 hours, the mixture is cooled to 5 C. After 1 hour, the product is isolated by filtration. 136.8 g of crude product are obtained, and this is washed with twice 200 ml of acetone and dried in a drying oven under reduced pressure at 450 C. to give 126.1 g of 2-isopropyl-4,5-dihydroxymethylimidazole of melting point 199.5-201.0 C. Evaporating down the filtrate gives 107 g of a crude product from which a further 18.5 g of 2-isopropyl-4,5-dihydroxymethylimidazole can be obtained by stirring with 107 g of methanol at 50 C. for 30 minutes and then cooling at 5 C. for 30 minutes, filtering and drying. The total yield is 84.8%. Elemental analysis: Mass spectrum: M+ 170. 1 H-NMR spectrum (solvent DDMSO): 1.12 1.24 (d, 6p) 2.9 (septet, 1p) 4.35 (s, 4p).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36947-68-9, its application will become more common.