Synthetic Route of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 13a (52 mg, 0.363 mmol) in anhydrous THF (5 mL) was added LDA (2 M in THF, 0.2 mL, 0.40 mmol) dropwise at -78 under nitrogen. The reaction mixture was stirred at -78 for 1 h, a solution of 10a (100 mg, 0.242 mmol) in anhydrous THF (1 mL) was added dropwise. The resulting reaction mixture was warmed slowly to room temperature, and stirred for another 3 h. The reaction mixture was quenched with water and extracted with EtOAc (5 mL x 3) . The combined organic layers were washed with brine (10 mL) , dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a residue, which was purified by preparative TLC (petroleum ether : EtOAc 4 : 1) to afford compound 13b (70 mg, 52yield) as a white solid.1H NMR (CD3OD, 400 MHz) : delta 7.62-7.55 (m, 3H) , 7.45-7.36 (m, 9H) , 7.32-7.20 (m, 8H) , 7.15 (s, 1H) , 5.65 (s, 1H) , 1.15 (s, 9H) , 1.01-0.87 (m, 3H) , 0.54-0.47 (m, 1H) MS 557.3 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1-Trityl-4-imidazolyl)benzaldehyde, its application will become more common.