Related Products of 104619-51-4, A common heterocyclic compound, 104619-51-4, name is Di(1H-imidazol-1-yl)methanimine, molecular formula is C7H7N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3-((2-hydroxy-3-nitrobenzyl)amino)propanenitrile (KR-400428) (3.87 mmol, 0.91 g) in methanol (125 mL), PtO2 (0.19 mmol, 0.04 g) was added. The reaction was flushed with argon followed by hydrogen for fifteen minutes each with constant magnetic stirring. The reaction was then stirred under hydrogen atmosphere at ordinary pressure (15 psi) for two hours. Argon was again flushed through the reaction vessel for 15 minutes. Then the reaction contents were filtered quickly over a thin pad of celite which was then immediately washed with methanol (75 mL). The filtrate was concentrated in vacuo yielding a brown oil. The oil was quickly re-dissolved in acetonitrile (175 mL) and di(imidazole-1-yl)methanimine (7.74 mmol, 1.25 g) was added with constant magnetic stirring. The reaction was then placed under argon atmosphere and refluxed for six hours. The reaction was concentrated under reduced pressure and silica gel column chromatography (20:1 ethyl acetate/methanol) provided faint brown crystals in a 67% yield. The product of the reduction (3-((3-amino-2-hydroxybenzyl)(methyl)amino)propanenitrile) is air sensitive and appropriate measures should be taken to minimize air exposure.
The synthetic route of 104619-51-4 has been constantly updated, and we look forward to future research findings.