Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1849-02-1, name is 2-Chloro-1-methyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1849-02-1
The product of preparation 16 (50mg, 0.19mmol), 2-chloro-1-methyl-1H-benzimidazole [(32mg, 0.19mmol), J. Heterocyclic. Chem, 34(6) 1781-1788; 1997] potassium phosphate, (45mg, 0.21mmol), palladium trifluoroacetate (cat.) and tri-tbutylphosphine (cat) were added to xylene (1mL) and the mixture was heated at 120C for 3 hours in a sealed Reactivial tube. Additional tri-tbutylphosphine (1.8mg) was added and the mixture was heated for a further 18 hours. The reaction mixture was then dissolved in methanol and was purified by column chromatography on silica gel, eluding with ethyl acetate:methanol:0.88 ammonia, 100:0:0 to 80:20:2. The crude product was purified further by column chromatography on Biotage amino silica gel, eluding with pentane:ethyl acetate 100:0 to 0:100, to afford the title compound as a colourless oil in 9% yield, 7mg. 1H-NMR(CDCl3, 400MHz) delta: 1.79-1.90(m, 4H), 1.99-2.05(m, 2H), 2.50-2.65(brm, 6H), 3.10(m, 2H), 3.60(m, 2H), 3.64(s, 3H), 4.30(m, 2H), 4.48(s, 2H), 6.60(d, 1H), 7.19(m, 3H), 7.38(d, 1H), 7.60(m, 1H) MS APCI+ m/z 392 [MH]+
According to the analysis of related databases, 1849-02-1, the application of this compound in the production field has become more and more popular.