Synthetic Route of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 1 Ethyl 5-(4-(lH-imidazol- l-yl)phenyl)-4H-thieno[3,2-^]pyrrole-2-carboxylate Step- 1 : Preparation of 4-(lH-imidazol-l-yl)benzaldehyde To a solution of 4-fluorobenzaldehyde (1.0 g, 8.06 mmol) in DMF (3 mL) were added 1H- imidazole (2.1 g, 32.2 mmol) and K2C03 (2.2 g, 16.12 mmol). The reaction mass was heated at reflux for 6 h before it was diluted with water and was extracted with EtOAc. The organic layer was separated, dried, filtered and concentrated. The residue was purified by column chromatography to afford 1.0 g of the title product. 1H NMR (300 MHz, DMSO d6) delta 10.03 (s, 1H), 8.47 (s, 1H), 8.07-8.04 (d, = 8.4 Hz, 2H), 7.95-7.93 (m, 3H), 7.17 (s, 1H); MS (m/z): 173 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.