Reference of 172499-76-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 172499-76-2, name is Ethyl 3-(1H-imidazol-2-yl)propanoate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A suspension of tBuOK (1.1 equiv. or 2.2 equiv.) and the imidazole derivative (1.0 equiv.) in DMF (6 mL/mmol) was stirred at rt for 1 h. The reaction mixture was treated with the corresponding alkyl bromide or alkyl mesylate (1.3 equiv. or 2.0 equiv.) and the temperature was raised up to 60 C and stirred at this temperature for 72 h. The solution was then diluted with EtOAc (20 mL/mmol) and washed three times with brine and H2O. The organic layers were dried over MgSO4, filtered, and concentrated. The crude product was purified by CC.
The synthetic route of Ethyl 3-(1H-imidazol-2-yl)propanoate has been constantly updated, and we look forward to future research findings.