Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123470-47-3, name is 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, A new synthetic method of this compound is introduced below., Quality Control of 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione
Subsequently, 93.1 mg of 5,6-difluorobenzimidazole-2-thiol (0.5 mmol) was dissolved in 2 ml of N,N-dimethylformamide, and the solution was heated at 80 C. for 12 hr after the addition of 104 mul of triethylamine and 117 mg of ethyl 4-bromobutyrate. The reaction mixture was cooled, water was added, the mixture was extracted with diethyl ether, and the organic layer was concentrated in vacuo. The residue was purified by preparative thin layer chromatography (hexane-ethyl acetate=1:1), and the product was collected and dried to yield 113 mg of 4-(5,6-difluorobenzimidazole-2-ylthio)butyric acid ethyl ester (75% yield).
The synthetic route of 123470-47-3 has been constantly updated, and we look forward to future research findings.