Application of 144690-33-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 144690-33-5, name is Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 2; Potassium salt of 4-(l-hydroxy-l-methylethyl)-2-propyl-l-{4-[2-(tetrazol-5- yl)phenyl]phenyl}methylimidazole-5-carboxylic acid (4); Ethyl ester 3 (20 g) was dissolved in THF (80 ml) at 50 0C (60 minutes). After cooling to 25 0C, a 40% solution of KOH (10 ml) was added, and the mixture was stirred vigorously for 24 h. After adding ethyl acetate (10 ml), the solution cleared up (neutralization). After concentrating to ca. 40 ml in vacuo, the mixture was diluted with ethyl acetate (100 ml), and solid NaCl (20 g) was added. After separating the phases, the organic layer was filtered and concentrated to ca. 30 ml in vacuo. Methyl ethyl ketone (50 ml) was added to this solution, the mixture was concentrated to 30 ml in vacuo for the subsequent reaction.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.