Application of 89830-98-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89830-98-8 as follows.
Methyl 4-bromothiophene-2-carboxylate (3.32 g, 15.0 mmol),4-cyclopropyl-1H-imidazole (1.08 g, 10.0 mmol),Potassium carbonate (4.14g, 30.0mmol),Cuprous iodide (572 mg, 3.0 mmol),1,10-phenanthroline (720 mg, 3.63 mmol),It was added to 50 mL of toluene, and heated to 110 C under a nitrogen atmosphere for 48 hours. The system was cooled to 25 C, the solvent was removed by rotary evaporation, and the residue was applied to silica gel column chromatography (PE: EA = 3:1).The target product (120 mg, yield 4.8%) was obtained.
According to the analysis of related databases, 89830-98-8, the application of this compound in the production field has become more and more popular.