Electric Literature of 1072-84-0,Some common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Will be 1.34g (12mmol)Imidazole-4-carboxylic acid is dissolved in 40 ml of anhydrous methanol.Add 3ml concentrated sulfuric acid, heat and reflux at 69.6 C for 12h.The reaction was completed until TLC was detected. The reaction solution was spun dry, and sodium hydrogencarbonate was added to adjust to weak acidity.It was diluted with 60 ml of ethyl acetate and the organic phase was washed with saturated sodium chloride (20 ml).Dry over anhydrous sodium sulfate, suction filtration, spin dry,Methyl imidazole-4-carboxylate (yellow brown solid)1.31g,The yield was 79.1%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole-4-carboxylic acid, its application will become more common.