16265-04-6, name is 2-Chloro-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 16265-04-6
4 g of 98% sulfuric acid, 2.04 g of 2-chloroimidazole ((? 02 mol) was added to the three-necked flask, and the mixture was stirred at room temperature (? 5h,And then heated to 45 ~ 55 C, slowly dropping from 1. 9g95% fuming nitric acid (0. 03mol) and 5g 20% fuming sulfuric acid composition of the mixed acid, after dropping, the temperature to 110 C reaction lh, the end After the reaction solution was poured into ice water, the pH was adjusted to 3 to 4 with aqueous ammonia, filtered and the cake was dried to give a white powdery solid 2-chloro-4-nitroimidazole, 56 mg, yield 87.3% HPLC purity 99. 4%, melting point 218. 6 ~ 219.5 C.
The synthetic route of 16265-04-6 has been constantly updated, and we look forward to future research findings.