Related Products of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (1.4 g, 3.37 mmol, 1.0 equiv),Compound (2-(3-Fluoro-4-nitrophenyl)-2-oxoethyl)phosphoric acid dimethyl ester (0702-102) (1.36 g, 4.38 mmol, 1.3 equivalents) andCesium carbonate (2.2 g, 6.74 mmol, 2.0 eq.)Mixed in isopropyl alcohol (30 ml),The reaction was stirred at room temperature overnight.After the reaction was completed, quenched with water and extracted with dichloromethane. The organic phase was dried over anhydrous sodium sulfate, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=100/1-50/ 1) Purification,The product (Z)-1-(3-fluoro-4-nitrophenyl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-ene is obtained 1-ketone (1.8 g, yield: 92%).
The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.