Reference of 4238-71-5, The chemical industry reduces the impact on the environment during synthesis 4238-71-5, name is 1-Benzyl-1H-imidazole, I believe this compound will play a more active role in future production and life.
1-Benzyl-2-iodo-imidazol (Compound 50, Scheme 19) was prepared by adding n-BuLi, (2.5 M in Hexane, 15.2 ml, 39 mmol) to a stirred solution of diisopropylamine (5.8 ml, 41.1 mmol) in THF (30 ml) at 0 C. After 30 minutes of stirring, the temperature was lowered to -78 C. and Compound 49 (1-benzyl-imidazol, 5 grams, 31.6 mmol) in THF (20 ml) was added thereto. The temperature was then increased to 0 C. and the reaction mixture was stirred at the same temperature for 30 minutes, then cooled down to -78 C. and finally iodine (8.8 grams, 34.8 mmol) in THF (20 ml) was added to the reaction mixture. The reaction mixture was stirred at room temperature for 2 hours and was quenched with aqueous NH4Cl, extracted with ethyl acetate, and the organic layer was washed with brine, dried over Na2SO4, and evaporated under reduced pressure to afford a crude product which was purified by column chromatography using silica gel and ethyl acetate:Hexane (1:1) as eluent to afford Compound 50 as yellow solid (6.5 grams, 72% yield).1H NMR (500 MHz, CDCl3)-delta: 7.36-7.29 (m, 3H), 7.14-7.11 (m, 3H), 7.00 (s, 1H), 5.09 (s, 2H);13C NMR (125 MHz, CDCl3)-delta: 135.5, 132.9, 128.9, 128.2, 127.2, 123.3, 90.6, 53;MS (ESI), m/z: 285 (MH+), 307 (MNa+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.