Related Products of 2466-76-4, These common heterocyclic compound, 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
rac-3-acetyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (Starting Product for Example 19) A solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (2.5 mmol) in absolute THF (1 ml) was added at -78° C. to a freshly prepared solution of LDA (2.76 mmol) in absolute THF (2 ml) and was stirred at this temperature for 2 h. Then acetylimidazole (2.76 mmol) dissolved in THF (1.5 ml) was added dropwise and the reaction mixture was stirred overnight, with warming to room temperature. The addition of saturated ammonium chloride solution was followed by extraction three times with ether, the combined organic phases were washed with water and saturated sodium chloride solution, dried over sodium sulphate and the solvent was removed in a vacuum. After column chromatography purification on silica gel with hexane/EtOAc 5:1 the product is obtained as a yellow oil. tR 2.09; MS (neg. Ion.) m/z 240.41 [M-H]-. (J. Med. Chem. 1989, 32(2), 351-357).
The synthetic route of 2466-76-4 has been constantly updated, and we look forward to future research findings.