Reference of 172499-76-2, These common heterocyclic compound, 172499-76-2, name is Ethyl 3-(1H-imidazol-2-yl)propanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1,4-Difluoro-2-nitrobenzene 239 mg, ethyl 3-(1H-imidazol-2-yl)propanoate 252 mg, potassium carbonate 415 mg and N,N-dimethylacetamide 10 mL were heated at 100C for 64 hours. The reaction liquid was diluted with ethyl acetate and filtered. The filtrate was condensed under reduced pressure and subjected to silica gel chromatography (ethyl acetate) to provide 220 mg of the title compound. 1H-NMR(CDCl3, delta): 1.21(3H, t, J=7.3Hz), 2.6-3.0(4H, m), 4.08(2H, q, J=7.3Hz), 6.86(1H, d, J=1.5Hz), 7.08(1H, d, J=1.5Hz), 7.4-7.6(2H, m), 7.80(1H, dd, J=2.9, 7.5Hz). MS(m/z): 308(M++1), 187(base).
The synthetic route of 172499-76-2 has been constantly updated, and we look forward to future research findings.