Electric Literature of 17289-26-8, A common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
14.1 Methyl (E) -3- (l-methyl-lH-imidazol-4-yl) acrylate1 ml (5.5 mmol) of methyl diethylphosphonoacetate are added to a suspension of 220 mg (5.5 mmol) of sodium hydride at 60% in 5 ml of tetrahydrofuran cooled to 00C. After stirring for 1 h, 500 mg (4.5 mmol) of 1- methyl-lH-imidazole-4-carbaldehyde are added and the mixture is stirred for 4 hours at ambient temperature and then hydrolysed with water and extracted with ethyl acetate. The organic phase is washed with a saturated aqueous solution of sodium hydrogen carbonate, dried over magnesium sulphate, filtered and evaporated. The product obtained is precipitated from heptane and filtered. 430 mg of methyl (E) -3- (1-methyl-lH-imidazol- 4-yl) acrylate are obtained in the form of a yellow powder with a yield of 57%.
The synthetic route of 17289-26-8 has been constantly updated, and we look forward to future research findings.