Adding a certain compound to certain chemical reactions, such as: 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28890-99-5, Safety of 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole
Example 16 3.3 g (6.9 mmol) of bromo compound, 2.1 g (10 mmol) of 6H-benzimidazolo[1 ,2- a]benzimidazole, 0.39 g (2.1 mmol) of copper(l) iodide, 14 g (123 mmol) of trans-1 ,2- cyclohexanediamine and 4.8 g (23 mmol) of tri potassium phosphate in 30 ml of 1 ,4-dioxane are reflux for 24 h. The reaction mixture is cooled at room temperature and added 200 ml of 1 N aqueous hydrochloric acid. The inorganic solids are filtered, then the filtrate is extracted with dichloromethane. The organic layer is dried over sodium sulfate and concentrated in vacuo. Gradient column chromatography on silica gel with dichloromethane/ethyl acetate (dichloromethane100%, 95/5, 1/1 ) gives the product. Yield 2.4 g (58 %). 1H NMR (400 MHz, CDC ): delta 8.18 – 8.10 (m, 2H); 8.04 – 7.96 (m, 2H); 7.94 – 7.87 (m, 2H); 7.87 – 7.79 (m, 4H); 7.78 – 7.73 (m, 1 H); 7.71 – 7.59 (m, 5H); 7.43 – 7.32 (m, 7H); 7.31 – 7.27 (m, 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SAITO, Masatoshi; NAGASHIMA, Hideaki; (118 pag.)WO2017/178864; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem