Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H3F3N2
Example 153 1,3,3-Trimethy1.6 [4..(trifluoromethyl)imidazol.. 1y1]indo1in2..one A suspension of 6-bromo-i,3,3-trimethylindolin-2-one (example la, 25.0 mg, 0.098 mmol), 4- (trifluoromethyl)-1H-imidazole (20.094 mg, 0.148 mmol) and potassium carbonate (40.8 mg,0.295mmo1) in acetonitrile (2.Oml) in a microwave tube was sparged with argon for 5 minutes. Then Cul (3.749 mg, 0.02 mmol) and N,N?-dimethylethane-i,2-diamine (0.0040 ml, 0.034 mmol) were added and degas sing was repeated. The tube was sealed and the reaction mixture was heated to 90C under microwave irradiation. The reaction mixture was concentrated in vacuo. The residue was diluted with ethyl acetate and washed with 1 M aqueous HC1 solution. Theorganic layer was dried with sodium sulfate, filtered and the obtained solution concentrated in vacuo. The crude material was purified by silica gel chromatography using hexane/ ethyl acetate as eluent. The title compound was obtained as off-white solid (10 mg).MS ESI (m/z): 310.2 [(M+H)i
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 33468-69-8.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BRUNNER, Daniela; HILPERT, Hans; KOLCZEWSKI, Sabine; LIMBERG, Anja; MALBERG, Jessica; PRINSSEN, Eric; RIEMER, Claus; SHANKAR, Bavani G.; STOLL, Theodor; WO2014/202493; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem