Electric Literature of 760212-58-6, These common heterocyclic compound, 760212-58-6, name is 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Subsequently, the following reagents and solvents were added into the reaction vessel.2.40 g (5.2 mmol, 1.1 eq) of 2-pinacolate-6,12-dinaphthylchrysene:Intermediate Compound M2: 1.66 g (4.7 mmol, 1.0 eq)Toluene: 75 mLSodium carbonate aqueous solution: 25 mL (3.0 eq)Then, while stirring the reaction solution, the following reagents were further added.Pd (PPh3) 4: 274 mg (0.24 mmol, 0.05 eq)Ethanol: 25 mLSubsequently, the reaction solution was stirred for 2 hours while heating and refluxing. After completion of the reaction, the reaction solution was cooled. Subsequently, liquid separation operation was performed using water, and the organic layer was recovered. Subsequently, the obtained organic layer was concentrated under reduced pressure. Thus, a crude product was obtained. Subsequently, the resulting crude product was purified by silica gel column chromatography (eluent: toluene / ethyl acetate = 10/1), and the separated solution was concentrated under reduced pressure. Thus, a solid was obtained. Then, the resulting solid was subjected to slurry cleaning with methanol, followed by filtration. Thus, 2.82 g of the exemplified compound A11 (yield: 86.8%, HPLC purity: 99.8%) was obtained.
The synthetic route of 760212-58-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Canon Co., Ltd; Eiwawaki, Hironobu; O.O, Rui Hiroki; Jisina, Yuko; Murachbaki, Masanori; Takahashi, Tetsuro; (23 pag.)KR101489992; (2015); B1;,
Imidazole – Wikipedia,
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