Reference of 3584-66-5,Some common heterocyclic compound, 3584-66-5, name is 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole, molecular formula is C8H4Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
0.5 g of 2-trichloromethylbenzimidazole 3a-m was introduced in portions at 0C into 30 ml of 2N NaOH solution. The resulting solution was acidified (pH 3) using 2N HCI solution and stirred for 1 hour. The mixture was cooled, and the resulting precipitate was filtered off with suction and washed 2 x with WATER/ACETONITRILE (3: 1) and 2 x with diethyl ether. 4a: R = 5-Cl ; brown solid, yield: 97%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole, its application will become more common.
Reference:
Patent; MERCK PATENT GmbH; WO2005/4863; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem