641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
4-Methyl-3- { [4-(pyridin-3 -yl)pyrimidin-2-yl] amino } berizoic acid (1 Og), carbonyl diimidazole (6.9 g) and imidazole hydrochloride (5.1 g) was added to N-methylpyrrolidin-2-one (200 mL) in a round bottom flask under nitrogen atmosphere at room temperature and stirred for 60 nuns. The reaction mass was heated to 50-55C and stirred for an hour. 5-trifluoromethyl-3-[4-methyl-H1-imidazolyl] aniline (11.8 g) was added to the reaction mass at 50-55C under nitrogen atmosphere. The reaction mass was further heated to 95-105C ad stirred for 24 hrs. After completion of reaction, thereaction mass was cooled to 25-35C, 5% sodium hydroxide solution was added to it and stirred for 1.5 hrs. The precipitated solid was filtered, washed with water followed by acetone and then dried under vacuum at 50-55C to get the title compound (9.1 g).Purity by HPLC: 99.84%; Amine impurity: 0.04%; Acid impurity: 0.03%
The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LAURUS LABS PRIVATE LIMITED; CHAVA, Satyanarayana; GORANTLA, Seeta Rama Anjaneyulu; INDUKURI, Venkata Sunil Kumar; MOTURU, Venkata Rama Krishna Murthy; JAMJANAM, Srivardhana Rao; SELA, Venkata Purushottama Siva Prasad; WO2015/87343; (2015); A2;,
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