Related Products of 16265-04-6,Some common heterocyclic compound, 16265-04-6, name is 2-Chloro-1H-imidazole, molecular formula is C3H3ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To make PCA 1 4-(2-(dimethylamino)ethoxy)-5-methoxy-2-nitrobenzyl 2-chloro-1H-imidazole-1-carboxylate, carbonyldichloroimidazole (CDCl) was freshly prepared by dissolving 2-chloroimidazole (102 mg, 1.0 mmol) in THF (1.5 mL) and triphosgene (25 mg, 0.08 mmol) dissolved in THF (1.0 mL) was added to this. The resulting mixture was stirred for 30 min at room temperature and then filtered. The filtrate was concentrated in vacuo and dried under high vacuum for 5 min resulting in a white powder (1H NMR (300 MHz, DMSO-d6) delta7.70 (d, J=1.9 Hz, 2H), 7.14 (d, J=1.9 Hz, 2H)), which was immediately used without any further purification. The white powder was dissolved in THF (1.0 mL) and to this was added a solution of compound 4a (8 mg, 0.03 mmol) dissolved in THF (1.0 mL) and the resulting mixture was stirred for 5 min at room temperature. Next, DIPEA (35 muL, 0.20 mmol) was added and the reaction was stirred for an additional 5 min before concentrating in vacuo. The obtained yellow solid was immediately dissolved in DMSO (30 muL) resulting in a -1 M solution and stored at -80 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-1H-imidazole, its application will become more common.
Reference:
Patent; The Board of Trustees of the Leland Stanford Junior University; Velema, Willem Arend; Kool, Eric T.; (79 pag.)US2019/264205; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem