Application of 3034-50-2, The chemical industry reduces the impact on the environment during synthesis 3034-50-2, name is Imidazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.
To a cooled (0 C) solution of NaH (60 % oil dispersion, 832 mg, 20.8 mmol) and 4-formylimidazole (2.0 g, 20.8 mmol) in dry DMF (30 mL) was added dropwise iodomethane (1.5 mL, 23.0 mmol). The reaction mixture was stirred at rt for 1.5 hr. After quenching the reaction with water, the solvent was removed by evaporation. The residue was dissolved in water and extracted with CHCl3. The extracts were dried over MgSO4 and concentrated by evaporation. The residue was purified by flash column chromatography on SiO2 (CHCl3 ? CHCl3 : MeOH = 100 : 1 ? 50 : 1 ? 10 : 1) to give 36 (1.2 g, 53 %) as a pale yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fuchida, Hirokazu; Tabata, Shigekazu; Shindo, Naoya; Takashima, Ippei; Leng, Qiao; Hatsuyama, Yuji; Hamachi, Itaru; Ojida, Akio; Bulletin of the Chemical Society of Japan; vol. 88; 6; (2015); p. 784 – 791;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem