Synthetic Route of 30148-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Preparation of Ethyl 4-nitro-1-methylimidazole-2-carboxylate (10) Compound (17) was carefully dissolved in 1000 ml of concentrated sulfuric acid cooled to 0 C. 90% nitric acid (1 liter) was slowly added maintaining a temperature of 0 C. The reaction was then refluxed with an efficient condenser (-20 C.) in a well ventilated hood for 50 minutes. The reaction was cooled with an ice bath, and quenched by pouring onto 10 liters of ice. The resulting blue solution was then extracted with 20 liters of dichloromethane and the combined extracts were dried and concentrated in vacuo to yield a tan solid which was recrystallized from 22 liters of 21:1 carbon tetrachloride/ethanol. The resulting white crystals were collected by vacuum filtration to provide pure (10). (103 g, 22% yield). TLC (7:2 benzene/ethyl acetate) Rf 0.5, 1 H NMR (DMSO-d6) delta 8.61 (s, 1 H), 4.33 (1, 2 H, J=6.4 Hz), 3.97 (s, 3 H), 1.29 (t, 3 H, J=6.0 Hz); 13 C NMR (DMSO-d6) delta 158.2, 145.4, 135.3, 127.4, 62.2, 37.3, 14.5; IR(KBr) 3139, 1719, 1541, 1508, 1498, 1381, 1310, 1260, 1147, 1122, 995, 860, 827, 656; FABMS m/e 200.066 (M+H 200.067 calc. for C7 H10 N3 O4).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-methyl-1H-imidazole-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; California Institute of Technology; US6090947; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem