These common heterocyclic compound, 31722-49-3, name is 1H-Imidazole-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1H-Imidazole-2-carbonitrile
6.7. Synthesis of aR,2S,3R)-l-aH,l’H-2,2′-biimidazol-5-yl)butane-l,2,3,4- tetraolThe captioned compound was prepared by General Method B with the following alterations. To a solution of lH-imidazole-2-carbonitrile (0.39 g, 4.17 mmol) in methanol (4.8 ml) was added a solution of sodium methoxide in methanol (25 wt%, 0.54 g, 0.57 ml, 2.50 mmol), stirred for 16 h and compound 8 (0.964 g, 4.17 mmol) was added in 10 ml of MeOH. A precipitate formed and was filtered and washed with acetone (15 ml). The filtrate was concentrated to dryness, and was purified by preparative HPLC (10 mM aq ammonium acetate/acetonitrile) to give the title compound (0.0141 g, 0.0554 mmol) as an off-white solid. MS m/z Ci0Hi4N4O4 [M + H] + = 255; 1H NMR (400 MHz, CD3OD) delta 3.56-3.57 (m, 2H), 3.67-3.74 (m, 2H), 4.90 (s, IH), 7.04 (s, IH).
The synthetic route of 1H-Imidazole-2-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; WO2008/109314; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem