Synthetic Route of 60-56-0,Some common heterocyclic compound, 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, molecular formula is C4H6N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of pyridine (1 mmol) in 3 mL dichloromethane was added dropwise to a magnetically stirred solution of 2-mercapto-1-methylimidazole or 5-mercapto-1-methyltetrazole (1 mmol) and acetylenic esters (1 mmol) in 15 mL dichloromethane. The reaction mixture was then stirred for 2 h at room temperature. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography using hexane-ethyl acetate as eluent. The solvent was removed under reduced pressure to afford the product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-2(3H)-thione, its application will become more common.
Reference:
Article; Asgharian-Sheykhi, Fahimeh; Hassanabadi, Alireza; Akhgar, Mohammad Reza; Karbalaei-Harofteh, Mina; Khajehpour, Ehsan; Journal of Chemical Research; vol. 37; 9; (2013); p. 523 – 525;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem